4-Benzyloxy-7-hydroxycoumarin → 7-(3-[4-Acetylphenyl]propoxy)-4-benzyloxycoumarin

Participants

Reaction Steps

Alkylation of 4-benzyloxy-7-hydroxycoumarin (2.68; 0.01 mole) with 1-(4-acetylphenyl)-3-bromopropane (2.41 g; 0.01 mole) as described in Example 45 gave 3.28 g (77%) of title compound of m.p. (EtOH) 117° νmax (mull) 1725, 1682, 1620 cm-1 ; τ(DMSO) 7.92 (2H, m); 7.48 (3H, s); 7.18 (2H, m); ; 5.94 (2H, t, J 6.4 Hz); 6.69 (2H, s); 6.16 (1H, s); 3.17-2.00 (12H, m). (Found; C, 75.14; H, 5.52; C21H24O5 requires; C, 75.68; H, 5.65%)

Provenance & Evidence