反应详情

67 parts of 4-methyl-5-chloromethyl-imidazole hydrochloride are dissolved in 200 parts of water and the mixture is stirred for 4.5 hours at 50°-60° C. The water is then substantially distilled off under reduced pressure from a waterpump and the crystal slurry is recrystallized from ethanol, the solution being cooled in ice. 43.4 parts (73%) of 4-methyl-5-hydroxymethyl-imidazole hydrochloride of melting point 238°-240° C. are obtained (the melting point given in the literature is 240°-242° C., cf. A. J. Ewins, J. Chem. Soc. 99 (1911), 2052.

1. distillationThe water is then substantially distilled off under reduced pressure from a waterpump
2. customthe crystal slurry is recrystallized from ethanol
3. temperaturethe solution being cooled in ice