Aniline → Indole

Participants

Reaction Steps

In like fashion, reaction of 3,4-pyridinedicarboxylic anhydride (Formula Vb hereinbelow) with an aniline of Formula VI or an indole of Formula VII (Z--H hereinbelow) produces a mixture of 3-(Z--CO)-4-pyridinecarboxylic acid (Formula IIc) and 4-(Z--CO)-3-pyridinecarboxylic acid (Formula IId). The mixture is in turn reacted with a diarylamine of Formula III to produce an isomeric mixture of furo[3,4-c]pyridine-1(3H)-one (Formula Ic) and furo[3,4-c]pyridine-3(1H)-one (Formula Id). ##STR22##

Provenance & Evidence