Quinoline → HCID 54439373, compound

Participants

Reaction Steps

To a solution of 10.0 g. ethyl 4-[6-(4-chlorophenyl)hexa-5-ynylamino]phenylacetate in 75 ml. acetone is added 1.0 ml. quinoline and 0.2 g. of palladium-on-calcium carbonate. The solution is hydrogenated at slightly above atmospheric pressure until 600 ml. hydrogen has been absorbed. The catalyst is filtered and washed with several small portions of acetone. The organic solution is diluted with 200 ml. water, the precipitate is collected, dried, and recrystallized from acetonitrile to yield the title compound as white crystals.

Provenance & Evidence