Sodium Hydroxide → Sodium 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoate

HRID 2057660Notes

Reaction equation

HRID 2057660 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]2[CH:30]=[CH:29][C:25]([C:26]([OH:28])=[O:27])=[CH:24][CH:23]=2)=[CH:4][CH:3]=1.[OH-].[Na+:32]>C(O)C.O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]2[CH:23]=[CH:24][C:25]([C:26]([O-:28])=[O:27])=[CH:29][CH:30]=2)=[CH:4][CH:3]=1.[Na+:32]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 203309694-[13-(4-Chlorophenyl)-12-tridecynylamino]benzoic acid

Product 1

HCID 23706318Sodium 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoate

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

A mixture of 3.62 g. of 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoic acid (Example 7) and 25 ml. of ethanol-water (9:1) containing 0.400 g. of sodium hydroxide is stirred for 4 hours. The mixture is filtered and the residue washed with 10 ml. of ethanol-water (9:1) and dried in vacuo for 24 hours to yield sodium 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoate as a white solid.

Workup

  1. additionA mixture of 3.62 g
  2. filtrationThe mixture is filtered
  3. washthe residue washed with 10 ml
  4. dry with materialof ethanol-water (9:1) and dried in vacuo for 24 hours

Sources & evidence

ORD record
ord-dc124d9f469d4b22a52080a419709155
Source dataset
uspto-grants-1980_07
Patent number
US04211783

Reaction notes

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