HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 3-Hydroxypropyl 1,3-propanediol 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 1,3-Propanediol | HCID 10442 | — |
| Reactant | Methyl 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoate | HCID 20330962 | — |
| Product | 3-Hydroxypropyl 1,3-propanediol 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoate | HCID 131711803 | — |
Reaction Steps
A mixture of 2.25 g. of methyl 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoate, 280 mg. of 1,3-propanediol and 1.37 g. p-toluenesulfonic acid is heated at 180° C. for 18 hours and then is partitioned between ether and 3% aqueous sodium carbonate solution. The ether layer is separated, dried, and evaporated to yield 3-hydroxypropyl 1,3-propanediol 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04211783 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-3d6397a869a6488eb049db0e476f0603 |
| Source note | uspto-grants-1980_07 |