Safrole → Safrole oxide

Participants

Reaction Steps

305 g of 5-(2-propenyl)-1,3-benzodioxole were reacted with 105 g of a 21.52% strength solution of perpropionic aicd in benzene at 32° C. as described in Example 1. After a reaction time of 2.5 hours, the peracid conversion was 98%. 5-(Oxiranylmethyl)-1,3-benzodioxole was formed with a selectivity of 85%. For working up, the reaction mixture was introduced into a distillation unit operating with a thin film evaporator and was separated into a top product, which contained benzene, propionic acid and unreacted 5-(2-propenyl)-1,3-benzodioxole, and into a bottom product, which consisted essentially of 5-(oxiranylmethyl)-1,3-benzodioxole. After redistillation of this bottom product, 37.0 g of 5-(oxiranylmethyl)-1,3-benzodioxole were obtained in a purity of 99.9%.

Provenance & Evidence