Formic Acid → HCID 54372587, compound

HRID 2057746Notes

Reaction equation

HRID 2057746 reaction equation
[C:1]1([NH:7][N:8]=[CH:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:16](OC=O)(=[O:18])C.C(O)=O.C(OC(=O)C)(=O)C>C(Cl)Cl>[CH:16]([N:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[N:8]=[CH:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=[O:18]

Participants

6

Reactant 4

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 75269Acetic-formic anhydrideHCID 2587553-[(2-Phenylhydrazinylidene)methyl]pyridine

Product 1

HCID 54372587HCID 54372587, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

9.85 g of 3 (prepared as described in Example 3) was dissolved in 50 ml of dry methylene chloride. 15 ml of formic acetic anhydride (prepared by mixing the appropriate amounts of formic acid and acetic anhydride) was added. The mixture was allowed to stand overnight at room temperature. The solvent was evaporated under reduced pressure. The residue was dissolved in ether. The solution was washed with sodium bicarbonate solution, dried (Na2SO4) and the solvent evaporated to give 4, as a white crystalline solid, mp 129°-132° C.

Workup

  1. additionwas added
  2. customThe solvent was evaporated under reduced pressure
  3. dissolutionThe residue was dissolved in ether
  4. washThe solution was washed with sodium bicarbonate solution
  5. dry with materialdried (Na2SO4)
  6. customthe solvent evaporated
  7. customto give 4

Sources & evidence

ORD record
ord-d749a427e2544d50b8c4b7888d1299c3
Source dataset
uspto-grants-1980_07
Patent number
US04212868

Reaction notes

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