Hydrochloric Acid → HCID 20330155, compound

Participants

Reaction Steps

The product of Step A is dissolved in 50 ml. of tetrahydrofuran and treated with 5 ml. of 1 N diborane in tetrahydrofuran at about 20° C. over a period of about 16 hours. The mixture is treated with 5 ml. of 6 N hydrochloric acid and heated on a steam bath for about 1/2 hour. 20 ml. of saturated sodium bicarbonate solution is added, the mixture is extracted with chloroform and the extracts are dried, then evaporated to provide a residue. The residue is recrystallized from a mixture of isopropanol and water to yield red needles of 5-benzylamino-2-nitro-3-phenylbenzofuran, m.p. 118°-120° C. having the structure ##STR12##

Provenance & Evidence