Hydrochloric Acid → HCID 20330143, compound

Participants

Reaction Steps

To a solution of 1.8 g. of 2-nitro-3-phenyl-5-propionamidobenzofuran in 50 ml. of tetrahydrofuran is added 10 ml. of 1 N diborane, and the solution is stirred for about 18 hours under a nitrogen atmosphere. To this mixture is cautiously added 5 ml. of 6 N hydrochloric acid. The mixture is heated to its reflux temperature and maintained at reflux for about 30 minutes. The solution is evaporated to provide a residue which is partitioned between cold sodium bicarbonate solution and chloroform. The chloroform extracts are dried, then evaporated to provide a red residue which is recrystallized from aqueous ethanol to provide red crystals of 2-nitro-3-phenyl-5-(n-propyl)aminobenzofuran, m.p. 158°-160° C.

Provenance & Evidence