Acetic Acid → HCID 20330179, compound

HRID 2057771Notes

Reaction equation

HRID 2057771 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([N+:10]([O-:12])=[O:11])=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:6]=2[CH:19]=1.C(O)(=O)C.[N-:24]=[C:25]=[O:26].[K+]>O>[N+:10]([C:8]1[O:9][C:5]2[CH:4]=[CH:3][C:2]([NH:1][C:25]([NH2:24])=[O:26])=[CH:19][C:6]=2[C:7]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)([O-:12])=[O:11]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 11051572Potassio isocyanateHCID 20330193HCID 20330193, compound

Product 1

HCID 20330179HCID 20330179, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
20 °C

Procedure

To a solution of 0.75 g. of 5-amino-2-nitro-3-phenylbenzofuran in 5 ml. of glacial acetic acid and 3 ml. of water is added an equimolar amount of potassium isocyanate dissolved in 5 ml. of warm water. The reaction is stirred at about 20° C. for 30 minutes then filtered to separate the solid product. The solid is recrystallized from aqueous methanol to provide yellow crystals of 2-nitro-3-phenyl-5-ureidobenzofuran, m.p. 230°-232° C.

Workup

  1. dissolutiondissolved in 5 ml
  2. filtrationthen filtered
  3. customto separate the solid product
  4. customThe solid is recrystallized from aqueous methanol

Sources & evidence

ORD record
ord-013448bebe61463081b6103f29f8840f
Source dataset
uspto-grants-1980_07
Patent number
US04212865

Reaction notes

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