Propyl isocyanate → HCID 20330144, compound

HRID 2057772Notes

Reaction equation

HRID 2057772 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([N+:10]([O-:12])=[O:11])=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:6]=2[CH:19]=1.[CH2:20]([N:23]=[C:24]=[O:25])[CH2:21][CH3:22]>C1C=CC=CC=1>[N+:10]([C:8]1[O:9][C:5]2[CH:4]=[CH:3][C:2]([NH:1][C:24]([NH:23][CH2:20][CH2:21][CH3:22])=[O:25])=[CH:19][C:6]=2[C:7]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)([O-:12])=[O:11]

Participants

4

Reactant 2

HCID 61033Propyl isocyanateHCID 20330193HCID 20330193, compound

Product 1

HCID 20330144HCID 20330144, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 2 g. of 5-amino-2-nitro-3-phenylbenzofuran in 100 ml. of hot benzene is added 4 ml. of n-propyl isocyanate. The mixture is heated on a steam bath for 30 minutes, then evaporated to dryness. The residue is recrystallized from aqueous methanol to provide orange crystals of 2-nitro-3-phenyl-5-(n-propyl)ureidobenzofuran, m.p. 199°-201° C., having the structure ##STR21##

Workup

  1. temperatureThe mixture is heated on a steam bath for 30 minutes
  2. customevaporated to dryness
  3. customThe residue is recrystallized from aqueous methanol

Sources & evidence

ORD record
ord-61c1be3740184135a2ab69fc32f6d6de
Source dataset
uspto-grants-1980_07
Patent number
US04212865

Reaction notes

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