Water → HCID 131711811, compound

Participants

Reaction Steps

3.429 g (1.5 mmoles) of H-Ile-Cys(Trt)-Ser-Leu-Tyr(But)-Gln-Leu-Glu(OBut)-Asn-Tyr(But)-Cys(Trt)-Asn-OBut trifluoroacetate are dissolved in a mixture of 19 ml of ethylmercaptan and 19 ml of trifluoroacetic acid. The reaction mixture is stirred for 4 hours at room temperature and is then poured into 250 ml of water, while stirring. The precipitate is filtered off, washed with ether and dried. It is then triturated with ether, filtered off and dried. Yield 1.964 g. This substance is then deblocked once more as described above. Yield 1.6 g (61%). In total, a further 330 mg of substance was obtainable from the filtrates after extraction with ether and freeze-drying.

Provenance & Evidence