Thionyl Chloride → HCID 23350227, compound

HRID 2057859Notes

Reaction equation

HRID 2057859 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][CH:10]([C:12]([OH:14])=O)[CH3:11])=[CH:4][C:3]=1[N:15]1[C:23](=[O:24])[N:18]2[CH2:19][CH2:20][CH2:21][CH2:22][C:17]2=[N:16]1.S(Cl)([Cl:27])=O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][CH:10]([C:12]([Cl:27])=[O:14])[CH3:11])=[CH:4][C:3]=1[N:15]1[C:23](=[O:24])[N:18]2[CH2:19][CH2:20][CH2:21][CH2:22][C:17]2=[N:16]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 23350230HCID 23350230, compound

Product 1

HCID 23350227HCID 23350227, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

3.7 Parts of 2-[2,4-dichloro-5-(1-carboxy-ethoxy)phenyl]-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-A]pyridin-3(2H)-one, 15 parts of chloroform and 1.2 parts of thionyl chloride were combined and refluxed for 3 hours. The reaction was stirred for an additional 12 hours at room temperature. Solvent and excess thionyl chloride were removed from the product by evaporation on a rotary evaporator at reduced pressure. 4.0 Parts of crude product were obtained and used in the next step without further purification.

Workup

  1. temperaturerefluxed for 3 hours
  2. customSolvent and excess thionyl chloride were removed from the product by evaporation on a rotary evaporator at reduced pressure
  3. custom4.0 Parts of crude product were obtained
  4. customused in the next step without further purification

Sources & evidence

ORD record
ord-715bc137e3a14a27a8016662e27aa94a
Source dataset
uspto-grants-1980_07
Patent number
US04213773

Reaction notes

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