HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 4-Amino-5-chloro-2-methoxy-N-(octahydro-2H-quinolizin-2-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 12783918 | HCID 12783918 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Amino-5-chloro-2-methoxy-N-(octahydro-2H-quinolizin-2-yl)benzamide | HCID 12783921 | 75% |
Reaction Steps
Hydrolysis of 4-acetylamino-5-chloro-2-methoxy-N-(2-quinolizidinyl)-benzamide (600 mg) with potassium hydroxide (500 mg) in ethanol (10 ml) and water (2 ml) at reflux for 4 hours followed by isolation through ether afforded one of the isomers of 4-amino-5-chloro-2-methoxy-N-(2-quinolizidinyl)-benzamide (400 mg), m.p. 175°-8°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04213983 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-7056ebe655bc44d4bbf2e3bd96525d7c |
| Source note | uspto-grants-1980_07 |