3-Chloropropionyl chloride → 11-(3-chloropropionyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

HRID 2057895Notes

Reaction equation

HRID 2057895 reaction equation
[Cl:1][CH2:2][CH2:3][C:4](Cl)=[O:5].[N:7]1[C:12]2[NH:13][C:14]3[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=3[C:16](=[O:18])[NH:17][C:11]=2[CH:10]=[CH:9][CH:8]=1>O1CCOCC1>[Cl:1][CH2:2][CH2:3][C:4]([N:13]1[C:14]2[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=2[C:16](=[O:18])[NH:17][C:11]2[CH:10]=[CH:9][CH:8]=[N:7][C:12]1=2)=[O:5]

Participants

4

Reactant 2

HCID 693643-Chloropropionyl chlorideHCID 701695,11-Dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one

Product 1

HCID 1381057111-(3-chloropropionyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Equimolar amounts of 3-chloropropionyl chloride and 5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one in solution in dioxane were reacted to obtain 11-(3-chloropropionyl)-5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one which melted at 216°-218° C. with decomposition.

Sources & evidence

ORD record
ord-d641112027914d94a0eebc5d63e50f36
Source dataset
uspto-grants-1980_07
Patent number
US04213985

Reaction notes

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