Sodium Carbonate → HCID 20329385, compound

Participants

Reaction Steps

A mixture of 9.5 g of the product of Step A, 3.2 g of sodium carbonate and 4 ml of 1-methyl-piperazine in 120 ml of ethanol was refluxed for 7 hours and the hot solution was then vacuum filtered. The filtrate was evaporated to a volume of about 50 ml and the crystalline precipitate was separated. Then the filtrate was evaporated to dryness in vacuo and the residue was crystallized from isopropanol to obtain a 36% yield of 5,11-dihydro-5-methyl-11-[2-(4-methyl-1-piperazinyl)-propionyl]-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one melting at 206°-208° C.

Provenance & Evidence