5,11-Dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one → HCID 20256761, compound

HRID 2057907Notes

Reaction equation

HRID 2057907 reaction equation
[Cl:1][CH:2]([CH3:6])[C:3](Cl)=[O:4].[N:7]1[C:12]2[NH:13][C:14]3[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=3[C:16](=[O:18])[NH:17][C:11]=2[CH:10]=[CH:9][CH:8]=1>O1CCOCC1>[Cl:1][CH:2]([CH3:6])[C:3]([N:13]1[C:14]2[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=2[C:16](=[O:18])[NH:17][C:11]2[CH:10]=[CH:9][CH:8]=[N:7][C:12]1=2)=[O:4]

Participants

4

Reactant 2

HCID 701695,11-Dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 1110192-Chloropropionyl chloride

Product 1

HCID 20256761HCID 20256761, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 2-chloropropionyl chloride and 5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepine-6-one in dioxane were reacted to obtain 11-(2-chloropropionyl)-5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one which melted at 215°-218° C. under crystallization from ethanol.

Sources & evidence

ORD record
ord-36a50f39206a4ccca132092425506ce2
Source dataset
uspto-grants-1980_07
Patent number
US04213985

Reaction notes

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