Ethyl chloroformate → HCID 20329448, compound

HRID 2057935Notes

Reaction equation

HRID 2057935 reaction equation
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH2:15][N:16](CC3C=CC=CC=3)[CH2:17][CH2:18][CH:19]=2)=[CH:10][C:9]=1[C:27]([F:30])([F:29])[F:28]>>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH2:15][N:16]([C:2]([O:4][CH2:5][CH3:6])=[O:3])[CH2:17][CH2:18][CH:19]=2)=[CH:10][C:9]=1[C:27]([F:30])([F:28])[F:29]

Participants

3

Reactant 2

HCID 10928Ethyl chloroformateHCID 3054979HCID 3054979, compound

Product 1

HCID 20329448HCID 20329448, compound

Procedure

2.5 ml of distilled ethyl chloroformate were added to a mixture of 5 g of 3-(4-chloro-3-trifluoromethylphenyl)-1-benzyl-1,2,5,6-tetrahydropyridine and 55 ml of anhydrous, distilled benzene and the mixture was refluxed with stirring under an inert atmosphere for 5 hours. The mixture was evaporated to dryness to obtain 5 g of ethyl 3-(4-chloro-3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydropyridine-1-carboxylate.

Workup

  1. distillationdistilled benzene
  2. temperaturethe mixture was refluxed
  3. customThe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-cbfa3b70d43b47bf9826666994477845
Source dataset
uspto-grants-1980_07
Patent number
US04213989

Reaction notes

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