Potassium Carbonate → HCID 20329506, compound

Participants

Reaction Steps

A mixture of 1-[2-chloro-4-(4-methoxyphenyl)-n-butyl]imidazole hydrochloride (prepared from 2.00 g. of alcohol as in Preparation C), 2-chlorothiophenol (2.80 g) and anhydrous potassium carbonate (2.70 g) in acetone (50 ml) was heated under reflux with stirring overnight. After removal of the solvent under reduced pressure, ether (150 ml) was added and the extract washed with water (2×30 ml) and dried (MgSO4) and the solvent removed to afford 1-[2-(2-chlorophenylthio)-4-(4-methoxyphenyl)-n-butyl]imidazole. Dropwise addition of 70% nitric acid (d-1.42) to an ethereal solution of this material until precipitation was complete gave the nitrate salt of 1-[2-(2-chlorophenylthio)-4-(4-methoxyphenyl)-n-butyl]imidazole, recrystallized from acetone/ethyl acetate as colorless microcrystals (3.10 g), mp 131.5°-133.5° C.

Provenance & Evidence