HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-[2-(2-Methoxyphenylthio)-4-(4-chlorophenyl)-n-butyl]imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Thioguaiacol | HCID 23642 | — |
| Reactant | 1-[2-Chloro-4-(4-chlorophenyl)butyl]-1H-imidazole | HCID 12432034 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-[2-(2-Methoxyphenylthio)-4-(4-chlorophenyl)-n-butyl]imidazole | HCID 20329531 | — |
Reaction Steps
1-[2-Chloro-4-(4-chlorophenyl)-n-butyl]imidazole (prepared from 2.0 g of alcohol as in Preparation D) was treated with 2-methoxythiophenol (1.68 g) and anhydrous potassium carbonate (1.60 g) in acetone using the procedure of Example 1 to afford 1-[2-(2-methoxyphenylthio)-4-(4-chlorophenyl)-n-butyl]imidazole which was converted to its nitrate salt and recrystallized from ethyl acetate to give 3.10 g of microcrystals, mp 105°-106.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04213991 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-d933a8ef63894ee786d7138ee7b2cb44 |
| Source note | uspto-grants-1980_07 |