HCID 178418361, compound → HCID 178428576, compound

HRID 2057952Notes

Reaction equation

HRID 2057952 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([N+:9]([O-])=O)[C:3]=1[N:12]=[C:13]1[NH:17][CH2:16][CH2:15][NH:14]1.[H][H]>[Ni].CO>[NH2:9][C:4]1[CH:5]=[C:6]([CH3:8])[CH:7]=[C:2]([Cl:1])[C:3]=1[N:12]=[C:13]1[NH:14][CH2:15][CH2:16][NH:17]1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178426129HCID 178426129, compound

Product 1

HCID 178428576HCID 178428576, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

3.05 gm (0.012 mol) of 2-(2-chloro-4-methyl-6-nitrophenylimino)-imidazolidine were hydrogenated in a shaker autoclave at 25°-30° C. and atmospheric pressure in the presence of Raney nickel and in a 1:1 mixture of methanol and tetrahydrofurn until the theoretical amount of hydrogen had been absorbed. Thereafter, the catalyst was separated by suction filtration, and the filtrate was evaporated in vacuo until the weight of the residue remained constant. Yield: 2.6 gm (96.5% of theory) of 2-(2-amino-6-chloro-4-methyl-phenylimino)-imidazolidine, an oily substance having an Rf -value of 0.3 in the mobile phase 50 parts benzene, 40 parts dioxane, 5 parts ethanol and 5 parts concentrated ammonium hydroxide; carrier: silicagel G; visualization: ultraviolet light and potassium iodoplatinate.

Workup

  1. customwere hydrogenated in a shaker autoclave at 25°-30° C.
  2. customhad been absorbed
  3. customThereafter, the catalyst was separated by suction filtration
  4. customthe filtrate was evaporated in vacuo until the weight of the residue

Sources & evidence

ORD record
ord-11bdc2059c7747a1b39d632be0b5ec4e
Source dataset
uspto-grants-1980_07
Patent number
US04213995

Reaction notes

Loading…