Sodium Carbonate → 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-1-((4-(2-methyl-2-propenyl)-1-piperazinyl)acetyl)-

Participants

Reaction Steps

8.62 gm of 11-chloroacetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one, 3.5 gm of sodium carbonate and 4.6 gm of 1-(2-methyl-allyl)-piperazine were refluxed in 100 ml of absolute ethanol for 2 hours. Then, the reaction mixture was suction-filtered while still hot, and the filtrate was evaporated to a volume of 40 ml and cooled. The precipitated crystals were recrystallized from ethanol in the presence of activated charcoal, yielding 75% of theory of the compound of the formula ##STR9## which had a melting point of 205°-207° C.

Provenance & Evidence