HuagongsheHuagongshe Chemistry Print Report · For research reference only
11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one → 11-[(4-Allyl-1-piperazinyl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b]-[1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one | HCID 120053 | — |
| Reactant | 1-Allylpiperazine | HCID 806422 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 11-[(4-Allyl-1-piperazinyl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b]-[1,4]benzodiazepin-6-one | HCID 20329368 | — |
Reaction Steps
8.62 gm of 11-chloroacetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 8.3 gm of 1-allyl-piperazine were refluxed in 100 ml of ethanol for 2 hours. The reaction mixture was then evaporated, and the crystalline precipitate was subsequently recrystallized from 30 ml of isopropanol and then from 94% ethanol in the presence of activated charcoal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04213984 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-926f375263f74647bb980e399e5da0fd |
| Source note | uspto-grants-1980_07 |