Water → HCID 70588408, compound

Participants

Reaction Steps

8.62 gm of 11-chloroacetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one and 8.7 gm of 1-(n-but-2-enyl)-piperazine (R1 =--CH2 --CH=CH--CH3) were refluxed in 100 ml of dioxane for 3 hours, and the reaction mixture was then evaporated in vacuo. The residue was purified on a silica gel column, and the obtained oily base was dissolved in 70 ml of hot isopropanol. The solution was acidified with hydrochloric acid, whereby the dihydrochloride crystallized out which was recrystallized from 94% ethanol. The obtained crystals included 2 mols of water of crystallization and melted at

Provenance & Evidence