HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-(tricyclo(3.3.1.1(sup 3,7))dec-1-ylmethyl)-1-piperazinyl)acetyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one | HCID 120053 | — |
| Reactant | HCID 44430191 | HCID 44430191 | — |
| Product | 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-(tricyclo(3.3.1.1(sup 3,7))dec-1-ylmethyl)-1-piperazinyl)acetyl)- | HCID 3053216 | — |
Reaction Steps
4.4 gm of 11-chloroacetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one, 1.8 gm of sodium carbonate and 3.75 gm of 1-(1-adamantyl-methyl-piperazine were reacted in 80 ml of absolute ethanol and worked up in analogy to Example 1. After recrystallization from a mixture of n-propanol and dimethylformamide; M.p.: 284°-287° C. (decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04213984 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-e775d72a44c048268304d2fe89397e8a |
| Source note | uspto-grants-1980_07 |