Potassium Permanganate → 5-Butyryl-1-methyl-benzimidazole-2-carboxylic acid

HRID 2058016Notes

Reaction equation

[C:1]([C:6]1[CH:17]=[CH:16][C:9]2[N:10]([CH3:15])[C:11]([CH2:13][OH:14])=[N:12][C:8]=2[CH:7]=1)(=[O:5])[CH2:2][CH2:3][CH3:4].[Mn]([O-])(=O)(=O)=[O:19].[K+]>>[C:1]([C:6]1[CH:17]=[CH:16][C:9]2[N:10]([CH3:15])[C:11]([C:13]([OH:19])=[O:14])=[N:12][C:8]=2[CH:7]=1)(=[O:5])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 516875Potassium Permanganate

HCID 130606785-Butyryl-1-methyl-benzimidazole-2-methanol

Product 1

HCID 128066555-Butyryl-1-methyl-benzimidazole-2-carboxylic acid

Procedure

In a manner analogous to that described in Example 12, 18.5 g of 5-butyryl-1-methyl-benzimidazole-2-methanol can be oxidised with 18.5 g of potassium permanganate to give 5-butyryl-1-methyl-benzimidazole-2-carboxylic acid with a melting point above 90° (decomposition).

Sources & evidence

ORD record: ord-7e918628b50247d8814c12b861991134
Source dataset: uspto-grants-1980_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04213993

Reaction notes

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