Potassium Permanganate → 5-Acetyl-1-n-butyl-benzimidazole-2-carboxylic acid

HRID 2058019Notes

Reaction equation

[C:1]([C:4]1[CH:18]=[CH:17][C:7]2[N:8]([CH2:13][CH2:14][CH2:15][CH3:16])[C:9]([CH2:11][OH:12])=[N:10][C:6]=2[CH:5]=1)(=[O:3])[CH3:2].[Mn]([O-])(=O)(=O)=[O:20].[K+]>>[C:1]([C:4]1[CH:18]=[CH:17][C:7]2[N:8]([CH2:13][CH2:14][CH2:15][CH3:16])[C:9]([C:11]([OH:20])=[O:12])=[N:10][C:6]=2[CH:5]=1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 516875Potassium Permanganate

HCID 13060682HCID 13060682, compound

Product 1

HCID 128066595-Acetyl-1-n-butyl-benzimidazole-2-carboxylic acid

Procedure

In a manner analogous to that described in Example 12, 4.9 g of 5-acetyl-1-n-butyl-benzimidazole-2-methanol can be oxidised with 4.5 g of potassium permanganate to give 5-acetyl-1-n-butyl-benzimidazole-2-carboxylic acid with a melting point>75° (decomposition).

Sources & evidence

ORD record: ord-83375e352b2140bd90fd662c8473f496
Source dataset: uspto-grants-1980_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04213993

Reaction notes

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