3-Bromo-4-(4-chlorophenyl)-4-oxobutanoic acid → HCID 131711831, compound

Participants

Reaction Steps

A mixture of 3-bromo-3-(p-chlorobenzoyl)propionic acid (11.64 g., 0.04 m.) and 2-mercapto-1-methylimidazole (4.56 g., 0.04 m.) is dissolved in glacial acetic acid by warming on a steam bath. After filtration of a small amount of insoluble material the filtrate is evaporated. The residue is washed with ether and then treated with dimethoxyethane and the solid weighing 10 g. is collected. The crude material is recrystallized from acetonitrile. The pure compound melts at 173°-5°.

Provenance & Evidence