Phosphorus pentachloride → HCID 20329754, compound

Participants

Reaction Steps

In 50 ml of ethyl acetate was dissolved 1.5 g of 7-nitro-1,2,3,4-tetrahydro-1-naphthoic acid. To the resulting solution was added at room temperature 1.3 g of phosphorus pentachloride, and the mixture was stirred for 30 minutes. The precipitates were removed by filtration and the filtrate was concentrated under reduced pressure. The residue was dissolved in 50 ml of fresh ethyl acetate. To the solution were added with cooling 1.0 g of phenol and 8.5 g of triethylamine. The resulting mixture was stirred for 24 hours. The reaction mixture was washed with a cold 5% sodium hydroxide solution and freed from the solvent by distillation to obtain 1.5 g of phenyl 7-nitro-1,2,3,4-tetrahydro-1-naphthoate having a melting point of 83°-84° C.

Provenance & Evidence