HCID 23349415, compound → HCID 23349421, compound

HRID 2058104Notes

Reaction equation

HRID 2058104 reaction equation
BrCC1C=C(Cl)C=CC=1N=C=O.BrCC1C=CC(Cl)=CC=1N=C=O.Br.[Cl:26][C:27]1[CH:39]=[CH:38][C:30]2[CH2:31][N:32]=[C:33]([N:35]([CH3:37])[CH3:36])[O:34][C:29]=2[CH:28]=1>>[Cl:26][C:27]1[CH:39]=[CH:38][C:30]2[CH2:31][N:32]=[C:33]([N:35]([CH3:36])[CH3:37])[O:34][C:29]=2[CH:28]=1

Participants

4

Reactant 3

HCID 23349415HCID 23349415, compoundHCID 23349429HCID 23349429, compoundHCID 23349430HCID 23349430, compound

Product 1

HCID 23349421HCID 23349421, compound

Procedure

Repeating the procedure of Step D of Example 1, but using in place of the 2-bromomethyl-4-chlorophenylisocyanate used therein, an approximately equal amount of 2-bromomethyl-5-chlorophenylisocyanate, there is accordingly obtained 7-chloro-2-dimethylamino-4H-1,3-benzoxazine hydrobromide (m.p. 173°-176°) which is converted to its free base form (m.p. 118°-120°) in the same manner as described in Step D of Example 1.

Sources & evidence

ORD record
ord-6f02499ffb7847e1837c3a7f339637a7
Source dataset
uspto-grants-1980_07
Patent number
US04214889

Reaction notes

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