HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → 1-[(Chloromethyl)thio]-4-fluorobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 4-Fluorothiophenol | HCID 67789 | — |
| Product | 1-[(Chloromethyl)thio]-4-fluorobenzene | HCID 20161342 | 99.8% |
Reaction Steps
This compound was prepared in the manner of Example 3.A., using 45.0 grams (0.35 mole) of a 4-fluorothiophenol, 13.5 grams (0.44 mole) of paraformaldehyde and 180 ml (1.8 moles) of concentrated hydrochloric acid in 90 ml of benzene. The residue was distilled under reduced pressure to give 61.9 grams (99.8%) of 4-fluorophenylthiomethyl chloride; b.p. 65° C./0.5 mm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04215069 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-a8a8b90b169847f2b81c9aea66e64d00 |
| Source note | uspto-grants-1980_07 |