N,N-Dimethylaminoethyl chloride hydrochloride → 2-(2-Dimethylaminoethylamino)-4-methyl-6-dimethylaminopyrimidine

HRID 2058160Notes

Reaction equation

HRID 2058160 reaction equation
[C:1]([NH:4][C:5]1[N:10]=[C:9]([CH3:11])[CH:8]=[C:7]([N:12]([CH3:14])[CH3:13])[N:6]=1)(=O)[CH3:2].Cl.[CH3:16][N:17](C)[CH2:18]CCl>>[CH3:16][N:17]([CH3:18])[CH2:2][CH2:1][NH:4][C:5]1[N:10]=[C:9]([CH3:11])[CH:8]=[C:7]([N:12]([CH3:14])[CH3:13])[N:6]=1

Participants

3

Reactant 2

HCID 11636816N,N-Dimethylaminoethyl chloride hydrochlorideHCID 233498782-Acetamido-4-methyl-6-dimethylaminopyrimidine

Product 1

HCID 233498692-(2-Dimethylaminoethylamino)-4-methyl-6-dimethylaminopyrimidine

Procedure

Following the procedure of Example 1, Part A 2-acetamido-4-methyl-6-dimethylaminopyrimidine and 2-dimethylaminoethyl chloride hydrochloride, 2-(2-dimethylaminoethylamino)-4-methyl-6-dimethylaminopyrimidine is obtained with a boiling point of 120°-124° C. at 0.03 mm.

Sources & evidence

ORD record
ord-013002db66694c59b939ac9725818c8d
Source dataset
uspto-grants-1980_07
Patent number
US04215121

Reaction notes

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