Sodium Hydroxide → HCID 21329146, compound

Participants

Reaction Steps

N,N-Dimethyl-N'-(2-dimethylaminoethyl)-N'-(6-chloro-3-pyridazinyl) urea hydrochloride (10.5 g, 0.034 mole) (Example 8) and 1.5 g of 5% palladium on carbon catalyst are added to a mixture of 35 ml of 2 N sodium hydroxide in 250 ml of ethyl alcohol. Treatment with hydrogen is performed in a Parr apparatus at 40-50 lbs. per sq. in. pressure and ambient temperature. The catalyst is removed by filtration, the filtrate is concentrated under reduced pressure, water is added and the mixture is extracted with benzene. The extracts are concentrated, the residue is dissolved in ether, hydrogen chloride is added and N,N-dimethyl-N'-(2-dimethylaminoethyl)-N'-(3-pyridazinyl) urea dihydrochloride melting at 187.5°-188.5° C. is obtained.

Provenance & Evidence