1-Chloro-2-dimethylamino-2-methylpropane hydrochloride → 2-(2-Methyl-2-dimethylaminopropylamino)-4-methyl-6-dimethylaminopyrimidine
Reaction equation
C([NH:4][C:5]1[N:10]=[C:9]([CH3:11])[CH:8]=[C:7]([N:12]([CH3:14])[CH3:13])[N:6]=1)(=O)C.Cl.[CH3:16][C:17]([N:21]([CH3:23])[CH3:22])([CH3:20])[CH2:18]Cl>>[CH3:16][C:17]([N:21]([CH3:23])[CH3:22])([CH3:20])[CH2:18][NH:4][C:5]1[N:10]=[C:9]([CH3:11])[CH:8]=[C:7]([N:12]([CH3:13])[CH3:14])[N:6]=1Participants
3
Procedure
Following the procedure of Example 1 part A using 2-acetamido-4-methyl-6-dimethylaminopyrimidine and 2-methyl-2-dimethylaminopropyl chloride hydrochloride, there is obtained 2-(2-methyl-2-dimethylaminopropylamino)-4-methyl-6-dimethyl minopyrimidine.
Workup
- customthere is obtained 2-(2-methyl-2-dimethylaminopropylamino)-4-methyl-6-dimethyl minopyrimidine
Sources & evidence
- ORD record
- ord-cb175f8b37434aa58c661752b6511842
- Source dataset
- uspto-grants-1980_07
- Patent number
- US04215121
Reaction notes
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