反应详情

To a cold solution of 5.4 g. (0.12 mole) of anhydrous ethyl amine in 5 ml. of ethanol was added 11.1 g. (0.06 mole) of 2-chloro-6-methylnicotinic acid methyl ester. The mixture was heated in a glass autoclave over a steam bath for 5 hours. The mixture was then evaporated in a rotary evaporator and the residue was added to 100 ml. of water and was basified with concentrated ammonium hydroxide. The mixture was then extracted with 100 ml. of chloroform. The chloroform layer was dried over magnesium sulfate, filtered and was evaporated to give 2-ethylamino-6-methylnicotinic acid methyl ester as an oil which was used without further purification.

1. temperatureThe mixture was heated in a glass autoclave over a steam bath for 5 hours
2. customThe mixture was then evaporated in a rotary evaporator
3. additionthe residue was added to 100 ml
4. extractionThe mixture was then extracted with 100 ml
5. dry with materialThe chloroform layer was dried over magnesium sulfate
6. filtrationfiltered
7. customwas evaporated