反应详情

A mixture of 1 g. of 1-ethyl-1,2-dihydro-4-hydroxy-7-methyl-2-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester (prepared as in Example 1) in 20 ml. of a saturated ethanolic ammonia solution was heated in an autoclave placed in a steam bath for 4 hours. The mixture was cooled and was filtered. The filter cake was triturated with 50 ml. of a 20% aqueous acetic acid solution. The insoluble material was collected, air dried and was recrystallized from ethanol to afford 0.4 g. of the title compound, m.p. 240°-2° C.

1. additionA mixture of 1 g
2. temperatureThe mixture was cooled
3. filtrationwas filtered
4. customThe filter cake was triturated with 50 ml
5. customThe insoluble material was collected
6. customair dried
7. customwas recrystallized from ethanol
8. customto afford 0.4 g