Ethanol → HCID 13952733, compound

Participants

Reaction Steps

To a solution of 0.11 g. (0.005 g. atoms) of sodium in 20 ml. of ethanol was added 1.47 g. (0.005 mole) of 1-ethyl-1,2-dihydro-4-chloro-7-methyl-2-oxo-1,8-naphthyridine-3-carboxylic acid, ethyl ester. The mixture was heated under reflux for 4 hours. The mixture was cooled and was diluted with water. The precipitate which formed was collected, air dried and was recrystallized from heptane to give 0.5 g. of the title compound, m.p. 77°-9° C.

Provenance & Evidence