1H-1,2,4-Triazole → HCID 23349974, compound

HRID 2058197Notes

Reaction equation

HRID 2058197 reaction equation
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.Br[CH:7]([O:15][C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:17]=1[Cl:23])[C:8](=[O:14])[C:9]([O:12][CH3:13])([CH3:11])[CH3:10].N12CCCCC1C=NCCC2>CC(C)=O>[Cl:23][C:17]1[CH:18]=[C:19]([Cl:22])[CH:20]=[CH:21][C:16]=1[O:15][CH:7]([N:1]1[CH:5]=[N:4][CH:3]=[N:2]1)[C:8](=[O:14])[C:9]([O:12][CH3:13])([CH3:11])[CH3:10]

Participants

5

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 3141121,5-Diazabicyclo(5,4,0)undec-5-eneHCID 23349975HCID 23349975, compound

Product 1

HCID 23349974HCID 23349974, compoundYield 63.8%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
0 °C

Procedure

1H-1,2,4-Triazole (2.83 g, 0.041 mole) was added to a stirred solution of 14.6 g (0.041 mole) of 1-bromo-1-(2,4-dichlorophenoxy)-3-methoxy-3-methyl-2-butanone in 100 ml. of acetone at -10° C. To the resulting mixture, 6.09 g (0.041 mole) of 1,5-diazabicyclo[5.4.0]-undec-5-ene was added at a rate to maintain the temperature of the mixture below -5° C. After the addition was complete, the mixture was stirred an additional 30 minutes at 0° C. Then the solvent was evaporated off, the residue taken up in 300 ml. diethyl ether, and the resulting mixture extracted with water. The organic phase was dried using MgSO4 and the solvent evaporated. The residual yellow oil (13 g) was stirred for several minutes with boiling hexane, then filtered to remove insoluble material. Upon cooling the filtrate, 9.0 g (63.8% yield) of 1-(2,4-dichlorophenoxy)-1-(1H- 1,2,4-triazol-1-yl)-3-methoxy-3-methyl-2-butanone, m.p. 53°-54° C., was obtained.

Workup

  1. customat -10° C
  2. temperatureto maintain the temperature of the mixture below -5° C
  3. additionAfter the addition
  4. customThen the solvent was evaporated off
  5. extractiondiethyl ether, and the resulting mixture extracted with water
  6. customThe organic phase was dried
  7. customthe solvent evaporated
  8. stirringThe residual yellow oil (13 g) was stirred for several minutes with boiling hexane
  9. filtrationfiltered
  10. customto remove insoluble material

Sources & evidence

ORD record
ord-513187510f3541ad984f7e847c02f20b
Source dataset
uspto-grants-1980_07
Patent number
US04215127

Reaction notes

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