HCID 178503877, compound → HCID 178433311, compound

Participants

Reaction Steps

A solution of silver nitrate (3.06 g.) in dimethyl formamide (20 ml.) was added to a solution of N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-S-methyl isothiourea (4.9 g.) in dimethylformamide (30 ml.). The resultant solution was kept at room temperature for 1 hour cooled and filtered to remove silver methylmercaptide, 4-methyl-5-((2-aminoethyl)thiomethyl)imidazole (3.07 g.) in dimethyl formamide (10 ml.) was added and this solution was heated overnight on the steam bath. Concentration followed by chromatographic purification of the product on a column of silica gel afforded the title compound (1.2 g.), m.p. 90°-94°, containing a small amount of water. (Found: C, 47.4; H, 5.9; N, 27.6; S, 15.5% C16H24N8S2 +3% H2O requires: C, 47.5; H, 6.3; N, 27.7; S, 15.8%).

Provenance & Evidence