反应详情

6.4 g of 2-(p-benzoylphenoxy)ethylamine and 17.2 g of chlorothioformic acid S-ethyl ester are dissolved in 230 ml of acetone, 22.2 g of potassium carbonate are added to the solution. The mixture is heated under reflux for 6 hours. After cooling to room temperature, the mixture is filtered, the residue is washed with acetone and the filtrate is evaporated in vacuo. The residue is suspended in hot ether and filtered. The residue is then washed with ether and the filtrate is evaporated in vacuo. Recrystallization of the residue from ether yields 2-(p-benzoylphenoxy)ethylthiocarbamic acid S-ethyl ester, m.p.--90°-92° C. Recrystallization of the mother liquor yields a further 1 g of product.

1. temperatureThe mixture is heated
2. temperatureunder reflux for 6 hours
3. filtrationthe mixture is filtered
4. washthe residue is washed with acetone
5. customthe filtrate is evaporated in vacuo
6. filtrationfiltered
7. washThe residue is then washed with ether
8. customthe filtrate is evaporated in vacuo
9. customRecrystallization of the residue from ether