Imidazole → HCID 23350210, compound

HRID 2058320Notes

Reaction equation

HRID 2058320 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.Cl[CH2:7][CH:8]([OH:18])[CH2:9][NH:10][C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1>>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([NH:10][CH2:9][CH:8]([OH:18])[CH2:7][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 23350206HCID 23350206, compound

Product 1

HCID 23350210HCID 23350210, compound

Procedure

Reaction of imidazole and N-(3-chloro-2-hydroxypropyl)-4-chloroaniline [Current Sci. (India) 4, 142-4 (1959)] yields 1-[3-(4-chloroanilino)-2-hydroxypropyl]-imidazole, M.P. 123°-125° C., which is in turn reacted with 2,4-dichlorobenzyl chloride to yield 1-[3-(4-chloroanilino)-2-(2,4-dichlorobenzyloxy)-propyl]-imidazole; M.P. of oxalate salt is 134°-135° C.; M.P. of hydrochloride salt is 161°-163° C.

Sources & evidence

ORD record
ord-c108e394186743babb9412d508fca915
Source dataset
uspto-grants-1980_07
Patent number
US04215220

Reaction notes

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