1-(Bromomethyl)-3-chlorobenzene → HCID 23350193, compound

HRID 2058321Notes

Reaction equation

HRID 2058321 reaction equation
[Cl:1][C:2]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:3]=1[NH:4][CH2:5][CH:6]([OH:13])[CH2:7][N:8]1[CH:12]=[CH:11][N:10]=[CH:9]1.[Cl:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=1)[CH2:23]Br>>[Cl:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=1)[CH2:23][O:13][CH:6]([CH2:5][NH:4][C:3]1[CH:14]=[CH:15][C:16]([Cl:18])=[CH:17][C:2]=1[Cl:1])[CH2:7][N:8]1[CH:12]=[CH:11][N:10]=[CH:9]1

Participants

3

Reactant 2

HCID 698381-(Bromomethyl)-3-chlorobenzeneHCID 23350201HCID 23350201, compound

Product 1

HCID 23350193HCID 23350193, compound

Procedure

Reaction of 1-[3-(2,4-dichloroanilino)-2-hydroxypropyl]-imidazole with 3-chlorobenzyl bromide yields 1-[2-(3-chlorobenzyloxy)-3-(2,4-dichloroanilino)-propyl]-imidazole; M.P. of oxalate salt is 118°-119° C.

Sources & evidence

ORD record
ord-a29aa652efb743ed95a9bd5df5cd5836
Source dataset
uspto-grants-1980_07
Patent number
US04215220

Reaction notes

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