HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Cysteamine | HCID 6058 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Butylamine | HCID 8007 | — |
| Reactant | Dibutylamine | HCID 8148 | — |
| Reactant | n-Methyl-1-(4-methyl-1h-imidazol-5-yl)methanamine | HCID 13316650 | — |
| Reactant | 4-(N-butylaminomethyl)-5-methylimidazole | HCID 23462128 | — |
| Reactant | 4-(N,N-dibutylaminomethyl)-5-methylimidazole | HCID 23462152 | — |
| Product | 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride | HCID 3015999 | — |
Reaction Steps
By the same procedure, using methylamine in place of dimethylamine, 4-(N-methylaminomethyl)-5-methylimidazole is prepared. In the same way, using butylamine and dibutylamine, 4-(N-butylaminomethyl)-5-methylimidazole and 4-(N,N-dibutylaminomethyl)-5-methylimidazole are prepared. Refluxing these intermediates with cysteamine by the above procedure and treating with hydrochloric acid gives 4-(2-aminoethyl)thiomethyl-5-methylimidazole dihydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04215217 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-51188516ebe7488a87176d273125362b |
| Source note | uspto-grants-1980_07 |