HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl O-tert-butyl-L-tyrosinate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Z-Tyr(tbu)-ome | HCID 7019804 | — |
| Catalyst | Pd barium sulfate | HCID 16218511 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl O-tert-butyl-L-tyrosinate hydrochloride | HCID 6452451 | — |
Reaction Steps
300 g (778 mmols) of Z-Tyr(But)-OMe (Ann. Chem. 696, page 226 (1966)) were dissolved in 1 l of methanol and catalytically hydrogenated (Pd/BaSO4 catalyst) at pH 4.5 on the autoburette (addition of about 2 N methanolic HCl). When the hydrogenation was complete, the catalyst was filtered off with suction and the filtrate was concentrated. The residue was triturated with ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04215037 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-fc7ece1ab4804c53a69a69978249eb9c |
| Source note | uspto-grants-1980_07 |