Pyridine → HCID 131711838, compound

Participants

Reaction Steps

24 g (about 10 mmols) of Ddz-Ile-Cys(Trt)-Ser-Leu-Tyr(But)-Gln-Leu-Glu(OBut)-Asn-Tyr(But)-Cys(Trt)-Asn-OBut were dissolved in a mixture of 8.75 ml (100 mmols) trifluoroacetic acid, 1.75 ml of water, 165 ml of methylene chloride (=about 175 ml of a 5% strength trifluoroacetic acid-methylene chloride solution with 1% of water) and 17.5 ml anisole while stirring. Stirring was continued for 4 hours at room temperature, 10 ml (124 mmols) pyridine were then added and the mixture was concentrated. The residue was triturated with ether, filtered of with suction, washed with ether and dried in vacuo. Next, the substance was triturated with water, filtered off with suction, washed with water and dried over P2O5.

Provenance & Evidence