HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 12837427, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | HCID 54325637 | HCID 54325637 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 12837427 | HCID 12837427 | — |
Reaction Steps
The (5α,20R)-4-benzoyl-3-oxopregnane-20-carboxaldehyde (436 mg, 1.0 mmole) in tetrahydrofuran:methanol (2.0 ml, 1:1) is mixed with sodium borohydride (9.5 mg, 0.25 mmole) at 0° C. for 1 hours. The mixture is then diluted with ether and washed with 0.5 N hydrochloric acid and brine and then dried and the solvent is evaporated to leave, as a resiue, (5α,20R)-4-benzoyl-21-hydroxy-20 -methylpregnan-3-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04317817 |
| Source dataset | uspto-grants-1982_03 |
| ORD ID | ord-5c1b8e3058744a84b30a72c1aa8cc9eb |
| Source note | uspto-grants-1982_03 |