1-(3,4-Difluorobenzoyl)azetidine → HCID 178461814, compound

HRID 20585Notes

Reaction equation

HRID 20585 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][C:13]=1F)[C:5]([N:7]1[CH2:10][CH2:9][CH2:8]1)=[O:6].[OH:15][C:16]1[CH:17]=[C:18]([CH:34]=[C:35]([O:37][C@@H:38]([CH3:51])[CH2:39][O:40][Si](C(C)C)(C(C)C)C(C)C)[CH:36]=1)[C:19]([NH:21][C:22]1[CH:26]=[CH:25][N:24](C(OC(C)(C)C)=O)[N:23]=1)=[O:20]>>[N:7]1([C:5]([C:4]2[CH:11]=[CH:12][C:13]([O:15][C:16]3[CH:17]=[C:18]([CH:34]=[C:35]([O:37][C@@H:38]([CH3:51])[CH2:39][OH:40])[CH:36]=3)[C:19]([NH:21][C:22]3[CH:26]=[CH:25][NH:24][N:23]=3)=[O:20])=[C:2]([F:1])[CH:3]=2)=[O:6])[CH2:10][CH2:9][CH2:8]1

Participants

3

Reactant 2

HCID 593468591-(3,4-Difluorobenzoyl)azetidineHCID 59346873tert-butyl 3-[(3-hydroxy-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate

Product 1

HCID 178461814HCID 178461814, compound

Procedure

The synthesis of 1-(3,4-difluorobenzoyl)azetidine is described in Example 8, the synthesis of tert-butyl 3-[(3-hydroxy-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate is described below:

Sources & evidence

ORD record
ord-ac0851f920ae479d9188aeedfed70376
Source dataset
uspto-grants-2010_06
Patent number
US07745475B2

Reaction notes

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