反应详情

A mixture of 0.41 g of the aldehyde(prepared as described in Reference Example 1), 8 ml of ethanol and 78 mg of sodium borohydride was stirred at room temperature for 30 minutes. The reaction mixture was diluted with ethyl acetate, washed with water, and a saturated aqueous solution of sodium chloride, dried over sodium sulphate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel using a 4% V/V solution of ethanol in chloroform as eluent to give 0.33 g of the title compound having the following physical characteristics:

1. washwashed with water
2. dry with materiala saturated aqueous solution of sodium chloride, dried over sodium sulphate
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified by column chromatography on silica gel using a 4% V/V solution of ethanol in chloroform as eluent