HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → 4-Carbomethoxy-3-keto-2-methyltetrahydrothiophene oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 1,4-Anhydro-2,5-dideoxy-2-(methoxycarbonyl)-1-thiopent-3-ulose | HCID 12658698 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 4-Carbomethoxy-3-keto-2-methyltetrahydrothiophene oxime | HCID 73708224 | 99% |
Reaction Steps
A solution of 37.26 g. (0.214 mole) of 4-carbomethoxy-3-keto-2-methyltetrahydrothiophene in 100 ml. anhydrous pyridine was treated with 18.0 g. (0.261 mole) hydroxylamine hydrochloride. The mixture was stirred 24 hours at 25°. The reaction was concentrated and partitioned between 1 N hydrochloric acid/methylene chloride. The aqueous phase was extracted two times with methylene chloride. The combined organic extracts were dried and evaporated to yield 40.1 g (99%) of pure 4-carbomethoxy-3-keto-2-methyltetrahydrothiophene oxime as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04317915 |
| Source dataset | uspto-grants-1982_03 |
| ORD ID | ord-a653b4fa592b4dd38caa229651a1a4bf |
| Source note | uspto-grants-1982_03 |